The gene is called CISD2 and is located on chromosome 4. In mice deprived of this gene, signs of premature aging have been recognized as the discoloration of hair and loss of bone mass. An animal deprived of this gene is also showing signs of life expectancy decreasing by half.

A study 8 years ago had shown that modification of genes on chromosome 4 could increase life expectancy of a person dramatically, without designating a specific gene.

Dr. Tsai, head of the team of twelve researchers behind this discovery, said that research had identified, in mice, a new model for the Wolfram syndrome. This rare combination of type I diabetes, diabetes insipidus (especially affecting the kidneys), deafness, visual disturbances and loss of tone of the bladder associated with neurological damage.

A link has been established between the gene CISD2, the integrity of mitochondria (cell structures necessary for the energy storage cells) and aging. Scientists are now trying to find ways to revitalize the gene CISD2.

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